Endothelial prostaglandin I2 restrains eosinophil trafficking
نویسندگان
چکیده
Background Enhanced eosinophil extravasation into the tissue is a characteristic feature of bronchial asthma and other allergic diseases. The barrier-forming vascular endothelial cells release prostaglandin I2 (PGI2, prostacyclin) as the major prostanoid, and it has been previously observed that PGI2 receptor (IP)-deficient mice show enhanced eosinophilic inflammation in response to allergens. Our aim was to define the role of PGI2 in endothelial function and in eosinophil trafficking across endothelial monolayers.
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